a double-blind, placebo-controlled study of the aqueous extract of echium amoenum for patients with general anxiety disorder

نویسندگان

mehdi sayyah herbal medicine research center, jundishapur university of medical sciences, ahwaz, iran.

amir siahpoosh herbal medicine research center, jundishapur university of medical sciences, ahwaz, iran.

hamidreza khalili department of pharmacology, jundishapur university of medical sciences, ahwaz, iran.

alireza malayeri department of pharmacology, jundishapur university of medical sciences, ahwaz, iran.

چکیده

the aim of this study was to assess the efficacy and tolerability of the aqueous extract of echium amoenum in combination with ssris in patients with general anxiety disorder (gad). the study was an 8-week double-blind randomized clinical trial. thirty-seven adult outpatients who met the dsm-iv-tr criteria for gad based on the structured clinical interview participated in the trial. in this study, patients were randomly assigned to receive the aqueous extract (500 mg) plus fluoxetine or fluoxetine (20 mg/day) plus placebo. the results showed significant difference between the two groups in the treatment of gad. moreover, there was not any significant difference between the two groups in terms of observed side effects. e. amoenum is effective on anxiety disorder, especially in higher dosage, without any serious side effects.

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A Double-Blind, Placebo-Controlled Study of the Aqueous Extract of Echium amoenum for Patients with General Anxiety Disorder

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عنوان ژورنال:
the iranian journal of pharmaceutical research

جلد ۱۱، شماره ۲، صفحات ۶۹۷-۷۰۱

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